ENTRY       EC 6.5.1.1
NAME        DNA ligase (ATP)
            Polydeoxyribonucleotide synthase (ATP)
            Polynucleotide ligase
            Sealase
            DNA repair enzyme
            DNA joinase
CLASS       Ligases
            Forming phosphoric ester bonds
SYSNAME     Poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase
            (AMP-forming)
REACTION    ATP + (Deoxyribonucleotide)n + (Deoxyribonucleotide)m = AMP +
            Pyrophosphate + (Deoxyribonucleotide)n+m
SUBSTRATE   ATP
            (Deoxyribonucleotide)n
            (Deoxyribonucleotide)m
            (Ribonucleotide)n
            (Ribonucleotide)m
PRODUCT     AMP
            Pyrophosphate
            (Deoxyribonucleotide)n+m
            (Ribonucleotide)n+m
COMMENT     Catalyses the formation of a phosphodiester at the site of a
            single-strand break in duplex DNA. RNA can also act as substrate
            to some extent.
DISEASE     MIM: 126391  Ligase I, DNA, ATP-dependent; DNA ligase I deficiency
                         (3)
            MIM: 210900  Bloom syndrome; Bloom syndrome (2)
            MIM: 600940  Ligase III, DNA, ATP-dependent
            MIM: 601837  Ligase IV, DNA, ATP-dependent
MOTIF       PS: PS00333  E-G-[LIVMA]-[LIVM](2)-[KR]-x(5,8)-[YW]-[QEK]-x(2,6)-
                         [KRH]-x(3,5)-K-[LIVMFY]-K
            PS: PS00697  [EDQH]-x-K-x-[DN]-G-x-R-[GACV]
GENES       MJA: MJ0171(lig)
            MTH: MTH1580(lig)
            BSU: yoqV
            SYN: cdc9) sll1530(YDL164C
            SCE: YDL164C(CDC9)
            HSA: LIG1(Hs.1770) LIG2 LIG3(Hs.100299)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.5.1.1
            WIT (What Is There) Metabolic Reconstruction: 6.5.1.1
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