ENTRY       EC 6.4.1.2
NAME        Acetyl-CoA carboxylase
CLASS       Ligases
            Forming carbon-carbon bonds
SYSNAME     Acetyl-CoA:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + Acetyl-CoA + HCO3- = ADP + Orthophosphate + Malonyl-CoA
SUBSTRATE   ATP
            Acetyl-CoA
            Propanonyl-CoA
            Butanoyl-CoA
            HCO3-
PRODUCT     ADP
            Orthophosphate
            Malonyl-CoA
INHIBITOR   (RS)-2-[4-(3-Chloro-5-(trifluoromethyl-2-pyridyloxy)phenoxy]-
            $propionic acid
COFACTOR    Biotin
COMMENT     A biotinyl-protein. Also catalyses transcarboxylation; the plant
            enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
DISEASE     MIM: 200350  Acetyl-Coenzyme A carboxylase; Acetyl-CoA carboxylase
                         deficiency (1)
MOTIF       PS: PS00188  [GN]-[DEQ]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMA]-
                         x(3)-[LIVM]-x-[SA]
            PS: PS00866  [FYV]-P-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-x(3)-
                         [SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
GENES       MJA: MJ1229(accC)
            MTH: MTH1917
            ECO: b0185(accA) b2316(accD) b3255(accB)
            HIN: HI0406(accA) HI0971(accB) HI0972(accC) HI1260(accD)
            HPY: HP0370(accC) HP0557(accA) HP0950(accD)
            BSU: accA accB(fabE) accC(yqhX)
            SYN: sll0336(accD) sll0728(accA) slr0435(accB)
            SCE: YNR016C(FAS3)
            HSA: ACACA(ACAC)
STRUCTURES  PDB: 1BDO  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.4.1.2
            WIT (What Is There) Metabolic Reconstruction: 6.4.1.2
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