ENTRY       EC 6.4.1.1
NAME        Pyruvate carboxylase
            Pyruvic carboxylase
CLASS       Ligases
            Forming carbon-carbon bonds
SYSNAME     Pyruvate:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + Pyruvate + HCO3- = ADP + Orthophosphate + Oxaloacetate
SUBSTRATE   ATP
            Pyruvate
            HCO3-
PRODUCT     ADP
            Orthophosphate
            Oxaloacetate
COFACTOR    Biotin
            Manganese
            Zinc
            Acetyl-CoA
COMMENT     A biotinyl-protein containing manganese (animal tissues) or
            zinc (yeast). The animal enzyme requires acetyl-CoA.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00252  Alanine and Aspartate metabolism
            PATH: MAP00620  Pyruvate metabolism
DISEASE     MIM: 266150  Pyruvate carboxylase; Pyruvate carboxylase deficiency
                         (1)
MOTIF       PS: PS00188  [GN]-[DEQ]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMA]-
                         x(3)-[LIVM]-x-[SA]
            PS: PS00866  [FYV]-P-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-x(3)-
                         [SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
GENES       BSU: pycA(ylaP)
            SCE: YBR218C(PYC2) YGL062W(PYC1)
            HSA: PC(Hs.89890)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.4.1.1
            WIT (What Is There) Metabolic Reconstruction: 6.4.1.1
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