ENTRY EC 6.3.5.5
NAME Carbamoyl-phosphate synthase (glutamine-hydrolysing)
Carbamoyl-phosphate synthetase (glutamine-hydrolysing)
CLASS Ligases
Forming carbon-nitrogen bonds
Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME Carbon-dioxide:L-glutamine amido-ligase (ADP-forming,
carbamate-phosphorylating)
REACTION 2 ATP + L-Glutamine + CO2 + H2O = 2 ADP + Orthophosphate +
L-Glutamate + Carbamoyl phosphate
SUBSTRATE ATP
L-Glutamine
CO2
H2O
PRODUCT ADP
Orthophosphate
L-Glutamate
Carbamoyl phosphate
COMMENT Formerly EC 2.7.2.9.
Glutamine amidotransferase domian (type G) has SH protease-
like catalytic residues.
PATHWAY PATH: MAP00251 Glutamate metabolism
DISEASE MIM: 114010 CAD trifunctional protein of pyrimidine biosynthesis
MOTIF PS: PS00097 F-x-[EK]-x-S-[GT]-R-T
PS: PS00442 [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
[QE]-x-[LIVMFA]
PS: PS00482 D-[LIVMFYWSP]-H-[LIV]-H-[LIVF]-[RN]-x-[PG]
PS: PS00483 [GA]-[ST]-D-x-A-P-H-x(4)-K
PS: PS00866 [FYV]-P-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-x(3)-
[SG]-G-x-[AG]
PS: PS00867 [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
GENES MJA: MJ1019(carA) MJ1378 MJ1381
MTH: MTH996 MTH997 MTH998
ECO: b0032(carA) b0033(carB)
HPY: HP0919 HP1237
BSU: carA(cpa) carB(cpa) pyrAA pyrAB
SYN: sll0370(carB) sll1498(carA)
SCE: YJL130C(URA2) YJR109C(CPA2) YOR303W(CPA1)
DBLINKS University of Geneva ENZYME DATA BANK: 6.3.5.5
WIT (What Is There) Metabolic Reconstruction: 6.3.5.5
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