ENTRY       EC 6.3.5.4
NAME        Asparagine synthase (glutamine-hydrolysing)
            Asparagine synthetase (glutamine-hydrolysing)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME     L-Aspartate:L-glutamine amido-ligase (AMP-forming)
REACTION    ATP + L-Aspartate + L-Glutamine = AMP + Pyrophosphate +
            L-Asparagine + L-Glutamate
SUBSTRATE   ATP
            L-Aspartate
            L-Glutamine
PRODUCT     AMP
            Pyrophosphate
            L-Asparagine
            L-Glutamate
COMMENT     Type F glutamine amidotransferase.
PATHWAY     PATH: MAP00252  Alanine and Aspartate metabolism
            PATH: MAP00910  Nitrogen metabolism
DISEASE     MIM: 108370  Asparagine synthetase
MOTIF       PS: PS00443  <x(0,11)-C-[GS]-[IV]-[LIVMFYW]-[AG]
GENES       MJA: MJ1056 MJ1116
            MTH: MTH414
            ECO: b0674(asnB)
            BSU: asnB(asn) asnH(yxaN)
            SYN: slr1812
            SCE: YGR124W(ASN2) YPR145W(ASN1)
            HSA: ASNS
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.5.4
            WIT (What Is There) Metabolic Reconstruction: 6.3.5.4
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