ENTRY       EC 6.3.5.2
NAME        GMP synthase (glutamine-hydrolysing)
            GMP synthetase (glutamine-hydrolysing)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME     Xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
REACTION    ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O = AMP +
            Pyrophosphate + GMP + L-Glutamate
SUBSTRATE   ATP
            Xanthosine 5'-phosphate
            L-Glutamine
            H2O
PRODUCT     AMP
            Pyrophosphate
            GMP
            L-Glutamate
INHIBITOR   Psicofuranin
COMMENT     Psicofuranine, 6-amino-9-D-psiscofuranosylpurine, prevents
            reaction of adenyl-XMP with NH3. Glutamine amidotransferase
            domian (type G) has a SH protease-like catalytic residues.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00251  Glutamate metabolism
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QE]-x-[LIVMFA]
GENES       MJA: MJ1131 MJ1575
            MTH: MTH709 MTH710
            ECO: b2507(guaA)
            HIN: HI0222(guaA)
            HPY: HP0409(guaA)
            BSU: guaA(guaB)
            SYN: slr0213(guaA)
            SCE: YMR217W(GUA1)
STRUCTURES  PDB: 1GPM  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.5.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.5.2
///