ENTRY       EC 6.3.4.5
NAME        Argininosuccinate synthase
            Citrulline--aspartate ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     L-Citrulline:L-aspartate ligase (AMP-forming)
REACTION    ATP + L-Citrulline + L-Aspartate = AMP + Pyrophosphate +
            N(omega)-(L-Arginino)succinate
SUBSTRATE   ATP
            L-Citrulline
            L-Aspartate
PRODUCT     AMP
            Pyrophosphate
            N(omega)-(L-Arginino)succinate
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00252  Alanine and Aspartate metabolism
            PATH: MAP00330  Arginine and proline metabolism
DISEASE     MIM: 215700  Argininosuccinate synthetase; Citrullinemia (3)
MOTIF       PS: PS00564  A-[FY]-S-G-G-L-D-T-S
            PS: PS00565  G-x-T-x-K-G-N-D-x(2)-R-F
GENES       MJA: MJ0429(argG)
            MTH: MTH1254
            ECO: b3172(argG)
            HIN: HI1727(argG)
            BSU: argG
            SYN: slr0585(argG)
            SCE: YOL058W(ARG1)
            HSA: ASS(ASS1)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.4.5
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.5
///