ENTRY       EC 6.3.4.3
NAME        Formate--tetrahydrofolate ligase
            Formyltetrahydrofolate synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Formate:tetrahydrofolate ligase (ADP-forming)
REACTION    ATP + Formate + Tetrahydrofolate = ADP + Orthophosphate +
            10-Formyltetrahydrofolate
SUBSTRATE   ATP
            Formate
            Tetrahydrofolate
PRODUCT     ADP
            Orthophosphate
            10-Formyltetrahydrofolate
COMMENT     In eukaryotes occurs as a trifunctional enzyme also having
            methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and
            methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00670  One carbon pool by folate
            PATH: MAP00790  Folate biosynthesis
DISEASE     MIM: 172460  5,10-methylenetetrahydrofolate dehydrogenase,
MOTIF       PS: PS00721  G-[LIVM]-K-G-G-A-A-G-G-G-Y
            PS: PS00722  V-A-T-V-R-A-L-K-x-[HN]-G-G
            PS: PS00766  [EQ]-x-E-[LIVM](2)-x(2)-[LIVM]-x(2)-[LIVM]-N-x-D-x(5)-
                         [LIVMF](3)-Q-L-P-[LV]
            PS: PS00767  P-G-G-V-G-P-[MF]-T-V
GENES       SCE: YBR084W(MIS1) YGR204W(ADE3)
            HSA: MTHFD(MTHFC)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.4.3
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.3
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