ENTRY       EC 6.3.4.2
NAME        CTP synthase
            UTP--ammonia ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     UTP:ammonia ligase(ADP-forming)
REACTION    ATP + UTP + NH3 = ADP + Orthophosphate + CTP
SUBSTRATE   ATP
            UTP
            NH3
            Glutamine
PRODUCT     ADP
            Orthophosphate
            CTP
            Glutamate
COMMENT     Glutamine can replace NH3.
            Glutamine amidotransferase domian (type G) has SH protease-
            like catalytic residues.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DISEASE     MIM: 123860  Cytidine 5'-triphosphate synthetase
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QE]-x-[LIVMFA]
GENES       MJA: MJ1174(pyrG)
            MTH: MTH419
            ECO: b2780(pyrG)
            HIN: HI1077(pyrG)
            HPY: HP0349(pyrG)
            BSU: ctrA(pyrG)
            SYN: sll1443(pyrG)
            SCE: YBL039C(URA7) YJR103W(URA8)
            HSA: CTPS(Hs.84112)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.4.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.2
///