ENTRY       EC 6.3.2.6
NAME        Phosphoribosylaminoimidazolesuccinocarboxyamide synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase
            (ADP-forming)
REACTION    ATP + 1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole +
            L-Aspartate = ADP + Orthophosphate +
            1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
SUBSTRATE   ATP
            1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole
            L-Aspartate
PRODUCT     ADP
            Orthophosphate
            1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 172439  Phosphoribosylaminoimidazole carboxylase
MOTIF       PS: PS01057  [LIVMF](2)-P-[LIVM]-E-x-[LIVM]-[LIVMC]-R-x(3)-[TA]-G-S
            PS: PS01058  [LIVM]-[LIVMA]-D-x-K-[LIVMFY]-E-F-G
GENES       MJA: MJ1592
            MTH: MTH170
            ECO: b2476(purC)
            HIN: HI1726(purC)
            BSU: purC
            SYN: slr1226(purC)
            SCE: YAR015W(ADE1)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.6
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.6
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