ENTRY       EC 6.3.2.4
NAME        D-Alanine-D-alanine ligase
            Alanylalanine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Alanine:alanine ligase (ADP-forming)
REACTION    ATP + Alanine + Alanine = ADP + Orthophosphate +
            D-Alanyl-D-alanine
SUBSTRATE   ATP
            Alanine
PRODUCT     ADP
            Orthophosphate
            D-Alanyl-D-alanine
INHIBITOR   Phosphinate
COMMENT     Transition-state analog inhibitor phosphinate (Science, 1994, 266,
            439-443).  Structure is similar to glutathione synthase
            (EC 6.3.2.3) from E. coli; Proc. Natl.Acad.Sci.USA, 1995, 92,
            1172-1176. Evolved from a common ancestor.
PATHWAY     PATH: MAP00473  D-Alanine metabolism
            PATH: MAP00550  Peptideglycan biosynthesis
            PATH: MAP00561  Glycerolipid metabolism
MOTIF       PS: PS00843  H-G-x(2)-G-E-D-G-x-[LIVMA]-[QS]-[GA]
            PS: PS00844  [LV]-G-x(2)-G-x-[SAG]-R-[LIVM]-D
GENES       ECO: b0092(ddlB) b0381(ddlA)
            HIN: HI1140(ddlB)
            HPY: HP0738(ddlA)
            BSU: ddlA(ddl)
            SYN: slr1874(ddlA)
STRUCTURES  PDB: 1IOV  1IOW  2DLN  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.4
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.4
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