ENTRY       EC 6.3.2.3
NAME        Glutathione synthase
            Glutathione synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     gamma-L-Glutamyl-L-cysteine:glycine ligase (ADP-forming)
REACTION    ATP + gamma-L-Glutamyl-L-cysteine + Glycine = ADP + Orthophosphate
            + Glutathione
SUBSTRATE   ATP
            gamma-L-Glutamyl-L-cysteine
            Glycine
PRODUCT     ADP
            Orthophosphate
            Glutathione
INHIBITOR   Phosphinate
COMMENT     Transition-state analog inhibitor phosphinate (J.Amer.Chem.Soc.,
            1994, 116, 12059-12060). Structure is similar to D-alanine-D-
            -alanine ligase (EC 6.3.2.4) from E. coli; Proc.Natl.Acad.Sci.USA,
            1995, 92, 1172-1176. Evolved from a common ancestor.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00480  Glutathione metabolism
DISEASE     MIM: 601002  Glutathione synthetase; Hemolytic anemia due to
                         glutathione synthetase deficiency, 231900 (3);
                         5-oxoprolinuria, 266130 (3)
GENES       ECO: b2947(gshB)
            SYN: slr1238(gshB)
            HSA: GSS(Hs.82327)
STRUCTURES  PDB: 1GSH  2GLT  1GSA  1GLV  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.3
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.3
            SCOP (Structural Classificaion of Proteins): 6.3.2.3
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