ENTRY       EC 6.3.2.25
NAME        Tublin-Tyrosine ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
REACTION    ATP + [alpha-Tublin] + L-Tyrosine = L-Tyrosyl-[alpha-Tublin]
            + ADP + Phosphate
SUBSTRATE   ATP
            [alpha-Tublin]
            L-Tyrosine
PRODUCT     L-Tyrosyl-[alpha-Tublin]
            ADP
            Phosphate
COMMENT     L-Tyrosine is linked Via a peptide bond to the C-Terminus
            of Detyrosinylated alpha-Tublin.
            The enzyme is extremely specific for alpha-Tublin and
            moderately specific for ATP and L-Tyrosine. L-Phenyl-
            alanine and 3,4-Dehydroxyl-L-phenylalanine are transferred,
            but with higher KM values.
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.25
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.25
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