ENTRY       EC 6.3.2.2
NAME        Glutamate--cysteine ligase
            gamma-Glutamylcysteine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     L-Glutamate:L-cysteine gamma-ligase (ADP-forming)
REACTION    ATP + L-Glutamate + L-Cysteine = ADP + Orthophosphate +
            gamma-L-Glutamyl-L-cysteine
SUBSTRATE   ATP
            L-Glutamate
            L-Cysteine
            L-Aminohexanoate
PRODUCT     ADP
            Orthophosphate
            gamma-L-Glutamyl-L-cysteine
INHIBITOR   S-Butyl-DL-homocysteine-[S,R]-sulfoximine
COMMENT     Can use L-aminohexanoate in place of glutamate.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00480  Glutathione metabolism
DISEASE     MIM: 230450  Glutamate-cysteine ligase (gamma-glutamylcysteine
                         synthetase),; Hemolytic anemia due to
                         gamma-glutamylcysteine synthetase deficiency (1)
            MIM: 601176  Glutamate-cysteine ligase (gamma-glutamylcysteine
                         synthetase),
GENES       ECO: b2688(gshA)
            SCE: YJL101C(GSH1)
            HSA: GLCLC(GCS) GLCLR(Hs.89709)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.2
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