ENTRY       EC 6.3.2.19
NAME        Ubiquitin--protein ligase
            Ubiquitin-activating enzyme
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Ubiquitin:protein-lysine N -ligase (AMP-forming)
REACTION    ATP + Ubiquitin + Protein lysine = AMP + Pyrophosphate +
            Protein N-ubiquityllysine
SUBSTRATE   ATP
            Ubiquitin
            Protein lysine
PRODUCT     AMP
            Pyrophosphate
            Protein N-ubiquityllysine
COMMENT     Ubiquitin is coupled to protein by a peptide bond between the
            C-terminal glycine of ubiquitin and epsilon-amino groups of
            lysine residues in the protein. An intermediate in the reaction
            contains one ubiquitin residue bound as a thiolester to the
            enzyme, and a residue of ubiquitin adenylate non-covalently
            bound to the enzyme.
DISEASE     MIM: 116948  Cell division cycle 34
            MIM: 179095  Ubiquitin-conjugating enzyme E2B (RAD6 homolog); ?Male
                         infertility (1)
            MIM: 312180  RAD6, yeast, human homolog of, type A
            MIM: 314370  Ubiquitin-activating enzyme E1 (teA1S9)
            MIM: 600012  Ubiquitin conjugating enzyme L-UBC
            MIM: 601661  Ubiquitin-conjugating enzyme E2I (homologous to yeast
                         UBC9)
MOTIF       PS: PS00183  [FYWLS]-H-[PC]-[NH]-[LIV]-x(3,4)-G-x-[LIV]-C-[LIV]-x-
                         [LIV]
GENES       SYN: PAS2) sll1355(YGR133W
            SCE: YBR082C(UBC4) YDL064W(UBC9) YDR054C(UBC3) YDR059C(UBC5)
                 YDR092W(UBC13) YDR177W(UBC1) YEL012W(UBC8) YER100W(UBC6)
                 YGL058W(UBC2) YGR133W(PAS2) YLR306W(UBC12) YMR022W(UBC7)
                 YOR339C(O6268)
            HSA: UBE1(GXP1) UBE2I(Hs.84285) UBE3A(E6-AP)
STRUCTURES  PDB: 1UCZ  1AAK  1U9B  1U9A  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.19
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.19
            SCOP (Structural Classificaion of Proteins): 6.3.2.19
///