ENTRY       EC 6.3.2.17
NAME        Tetrahydrofolylpolyglutamate synthase
            Folylpolyglutamate synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
REACTION    ATP + Tetrahydrofolyl-[Glu](n) + L-Glutamate = ADP +
            Orthophosphate + Tetrahydrofolyl-[Glu](n+1)
SUBSTRATE   ATP
            Tetrahydrofolyl-[Glu](n)
            L-Glutamate
PRODUCT     ADP
            Orthophosphate
            Tetrahydrofolyl-[Glu](n+1)
COMMENT     The enzymes from different sources (particularly eukaryotes
            versus prokaryotes) have different substrate specificities with
            regard to one-carbon substituents and the number of glutamate
            residues present on the tetrahydrofolates.
PATHWAY     PATH: MAP00790  Folate biosynthesis
DISEASE     MIM: 136510  Folylpolyglutamate synthetase
MOTIF       PS: PS01011  [LIVMFY]-x-[LIVM]-[STAG]-G-T-[NK]-G-K-x-[ST]-x(7)-
                         [LIVM](2)-x(3)-G
            PS: PS01012  [LIVMF](2)-E-x-G-[LIVM]-[GA]-G-x(2)-D-x-[GST]-x-
                         [LIVM](2)
GENES       ECO: b2315(folC)
            HIN: HI1261(folC)
            HPY: HP1545(folC)
            BSU: folC
            SYN: sll1612(folC)
            SCE: YKL132C
            HSA: FPGS
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.17
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.17
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