ENTRY       EC 6.3.2.15
NAME        UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-
            $diaminopimelate-D-alanyl-D-alanine ligase
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-
            $diaminopimeloyl-D-alanyl-D-alanine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-
            $diaminoheptanedioate:D-alanyl-D-alanine ligase(ADP-forming)
REACTION    ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-
            $diaminoheptanedioate + D-Alanyl-D-alanine = ADP + Orthophosphate
            + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-
            $carboxy-L-lysyl-D-alanyl-D-alanine
SUBSTRATE   ATP
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-
            $diaminoheptanedioate
            D-Alanyl-D-alanine
PRODUCT     ADP
            Orthophosphate
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-
            $carboxy-L-lysyl-D-alanyl-D-alanine
COMMENT     The enzyme from Bacillus subtillis also catalyses the reverse,
            hydrolytic, reaction in the presence of ADP, orthophosphate and
            Co2+. No formation of ATP, however, was observed.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00550  Peptideglycan biosynthesis
GENES       ECO: b0086(murF)
            HIN: HI1134(murF)
            BSU: murF(ydbQ)
            SYN: slr1351(murF)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.15
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.15
///