ENTRY       EC 6.3.2.12
NAME        Dihydrofolate synthase
            Dihydrofolate synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Dihydropteroate:L-glutamate ligase (ADP-forming)
REACTION    ATP + Dihydropteroate + L-Glutamate = ADP + Orthophosphate +
            Dihydrofolate
SUBSTRATE   ATP
            Dihydropteroate
            L-Glutamate
PRODUCT     ADP
            Orthophosphate
            Dihydrofolate
PATHWAY     PATH: MAP00790  Folate biosynthesis
MOTIF       PS: PS01011  [LIVMFY]-x-[LIVM]-[STAG]-G-T-[NK]-G-K-x-[ST]-x(7)-
                         [LIVM](2)-x(3)-G
            PS: PS01012  [LIVMF](2)-E-x-G-[LIVM]-[GA]-G-x(2)-D-x-[GST]-x-
                         [LIVM](2)
GENES       ECO: b2315(folC)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.2.12
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.12
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