ENTRY       EC 6.2.1.3
NAME        Long-chain-fatty-acid--CoA ligase
            Acyl-CoA synthetase
            Fatty acid thiokinase (long chain)
            Acyl-activating enzyme
            Palmitoyl-CoA synthase
            Lignoceroyl-CoA synthase
            Arachidonyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Acid:CoA ligase (AMP-forming)
REACTION    ATP + a Long-chain carboxylic acid + CoA = AMP + Pyrophosphate +
            an Acyl-CoA
SUBSTRATE   ATP
            Long-chain carboxylic acid
            Fatty acid
            CoA
PRODUCT     AMP
            Pyrophosphate
            Acyl-CoA
COFACTOR    Magnesium
COMMENT     Acts on a wide range of long-chain saturated and unsaturated
            fatty acids, but the enzymes from different tissues show some
            variation in specificity. The liver enzyme acts on acids from
            C6 to C20; that from brain shows high activity up to C24.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
DISEASE     MIM: 152425  Fatty-acid-Coenzyme A ligase, long chain 1
            MIM: 152426  Fatty-acid-Coenzyme A ligase, long-chain 2
MOTIF       PS: PS00455  [LIVMFY]-x(2)-[STG](2)-G-[ST]-[STEI]-[SG]-x-[PASLIVM]-K
GENES       MTH: MTH657
            ECO: b1805(fadD)
            HIN: HI0002 HI0389B(fadD)
            BSU: acsA lcfA yhfL yhfT
            SYN: slr1609
            SCE: YER015W(FAA2) YIL009W(FAA3) YMR246W(FAA4) YOR317W(FAA1)
            HSA: FACL1(Hs.89549) FACL2(FACL1)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.3
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