ENTRY EC 6.2.1.15
NAME Arachidonate--CoA ligase
Arachidonoyl-CoA synthetase
CLASS Ligases
Forming carbon-sulfur bonds
Acid--thiol ligases
SYSNAME Arachidonate:CoA ligase (AMP-forming)
REACTION ATP + Arachidonate + CoA = AMP + Pyrophosphate + Arachidonyl-CoA
SUBSTRATE ATP
Arachidonate
CoA
8,11,14-Eicosatrienoate
PRODUCT AMP
Pyrophosphate
Arachidonyl-CoA
8,11,14-Eicosatrienoyl-CoA
COMMENT Not identical with EC 6.2.1.3. 8,11,14-Eicosatrienoate, but not the
other long-chain fatty acids, can act in place of arachidonate.
DBLINKS University of Geneva ENZYME DATA BANK: 6.2.1.15
WIT (What Is There) Metabolic Reconstruction: 6.2.1.15
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