ENTRY       EC 6.2.1.1
NAME        Acetate--CoA ligase
            Acetyl-CoA synthetase
            Acetyl activating enzyme
            Acetate thiokinase
            Acyl-activating enzyme
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Acetate:CoA ligase (AMP-forming)
REACTION    ATP + Acetate + CoA = AMP + Pyrophosphate + Acetyl-CoA
SUBSTRATE   ATP
            Acetate
            CoA
            Propanoate
            Propenoate
PRODUCT     AMP
            Pyrophosphate
            Acetyl-CoA
            Propanoyl-CoA
            Propenoyl-CoA
COMMENT     Also acts on propanoate and propenoate.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
MOTIF       PS: PS00455  [LIVMFY]-x(2)-[STG](2)-G-[ST]-[STEI]-[SG]-x-[PASLIVM]-K
GENES       MTH: MTH1603 MTH1604 MTH216 MTH217 MTH701 MTH702
            ECO: b4069(acs)
            HPY: HP1045(acoE)
            BSU: acsA ytcI
            SYN: sll0542(acs)
            SCE: YAL054C(ACS1) YLR153C(ACS2)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.1
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