ENTRY       EC 6.1.1.6
NAME        Lysine--tRNA ligase
            Lysyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Lysine:tRNA(Lys) ligase (AMP-forming)
REACTION    ATP + L-Lysine + tRNA(Lys) = AMP + Pyrophosphate +
            L-Lysyl-tRNA(Lys)
SUBSTRATE   ATP
            L-Lysine
            tRNA(Lys)
PRODUCT     AMP
            Pyrophosphate
            L-Lysyl-tRNA(Lys)
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP01020  Protein biosynthesis (prokaryotes)
            PATH: MAP01030  Protein biosynthesis (eukaryotes)
DISEASE     MIM: 601421  Lysyl-tRNA synthetase
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
GENES       ECO: b2890(lysS) b4129(lysU) b4155(yjeA)
            HIN: HI0836(genX) HI1211(lysS)
            HPY: HP0182(lysS)
            BSU: lysS
            MGE: MG136(lysS)
            MPN: A65_orf489(lysS)
            SYN: slr1550(lysS)
            SCE: YDR037W(KRS1) YNL073W(MSK1)
STRUCTURES  PDB: 1LYL  1KRT  1KRS  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.6
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