ENTRY       EC 6.1.1.5
NAME        Isoleucine--tRNA ligase
            Isoleucyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Isoleucine:tRNA(Ile) ligase (AMP-forming)
REACTION    ATP + L-Isoleucine + tRNA(Ile) = AMP + Pyrophosphate +
            L-Isoleucyl-tRNA(Ile)
SUBSTRATE   ATP
            L-Isoleucine
            tRNA(Ile)
PRODUCT     AMP
            Pyrophosphate
            L-Isoleucyl-tRNA(Ile)
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP01020  Protein biosynthesis (prokaryotes)
            PATH: MAP01030  Protein biosynthesis (eukaryotes)
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-G-
                         [HNTG]-[LIVMFYSTAGPC]
GENES       MJA: MJ0947(ileS)
            MTH: MTH1375
            ECO: b0026(ileS)
            HIN: HI0962(ileS)
            HPY: HP1422(ileS)
            BSU: ileS
            MGE: MG345(ileS)
            MPN: G12_orf861(ileS)
            SYN: sll1362(ileS)
            SCE: YBL076C(ILS1) YPL040C(ISM1)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.1.1.5
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.5
///