ENTRY       EC 6.1.1.3
NAME        Threonine--tRNA ligase
            Threonyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Threonine:tRNA(Thr) ligase (AMP-forming)
REACTION    ATP + L-Threonine + tRNA(Thr) = AMP + Pyrophosphate +
            L-Threonyl-tRNA(Thr)
SUBSTRATE   ATP
            L-Threonine
            tRNA(Thr)
PRODUCT     AMP
            Pyrophosphate
            L-Threonyl-tRNA(Thr)
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP01020  Protein biosynthesis (prokaryotes)
            PATH: MAP01030  Protein biosynthesis (eukaryotes)
DISEASE     MIM: 187790  Threonyl-tRNA synthetase
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
GENES       MJA: MJ1197(thrS)
            MTH: MTH1455
            ECO: b1719(thrS)
            HIN: HI1367(thrS)
            HPY: HP0123(thrS)
            BSU: thrS(thrSV) thrZ(thrS2)
            MGE: MG375(thrS)
            MPN: G12_orf564(thrS)
            SYN: sll0078(thrS)
            SCE: YIL078W(THS1) YKL194C(MST1)
            HSA: TARS(Hs.84131)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.1.1.3
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.3
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