ENTRY       EC 6.1.1.21
NAME        Histidine--tRNA ligase
            Histidyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Histidine:tRNA(His) ligase (AMP-forming)
REACTION    ATP + L-Histidine + tRNA(His) = AMP + Pyrophosphate +
            L-Histidyl-tRNA(His)
SUBSTRATE   ATP
            L-Histidine
            tRNA(His)
PRODUCT     AMP
            Pyrophosphate
            L-Histidyl-tRNA(His)
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP01020  Protein biosynthesis (prokaryotes)
            PATH: MAP01030  Protein biosynthesis (eukaryotes)
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
            PS: PS00762  Q-G-[DE]-x-[LIV]-[KR]-x(2)-K-x(2)-[KN]-[AS]-x(4)-[LIV]-
                         [DENK]-x(2)-V-x(2)-L-x(3)-K
GENES       MJA: MJ1000(hisS)
            MTH: MTH244
            ECO: b2514(hisS)
            HIN: HI0369(hisS)
            HPY: HP1190(hisS)
            BSU: hisS
            MGE: MG035(hisS)
            MPN: B01_orf414o(hisS)
            SYN: slr0357(hisS1) slr1560(hisS2)
            SCE: YPR033C(HTS1)
            HSA: HARS(Hs.2741)
STRUCTURES  PDB: 1HTT  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.1.1.21
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.21
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