ENTRY       EC 6.1.1.2
NAME        Tryptophan--tRNA ligase
            Tryptophanyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Tryptophan:tRAN(Trp) ligase (AMP-forming)
REACTION    ATP + L-Tryptophan + tRNA(Trp) = AMP + Pyrophosphate +
            L-Tryptophanyl-tRNA(Trp)
SUBSTRATE   ATP
            L-Tryptophan
            tRNA(Trp)
PRODUCT     AMP
            Pyrophosphate
            L-Tryptophanyl-tRNA(Trp)
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP01020  Protein biosynthesis (prokaryotes)
            PATH: MAP01030  Protein biosynthesis (eukaryotes)
DISEASE     MIM: 191050  Tryptophanyl-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-G-
                         [HNTG]-[LIVMFYSTAGPC]
            PS: PS00762  Q-G-[DE]-x-[LIV]-[KR]-x(2)-K-x(2)-[KN]-[AS]-x(4)-[LIV]-
                         [DENK]-x(2)-V-x(2)-L-x(3)-K
GENES       MJA: MJ1415(trpS)
            MTH: MTH251
            ECO: b3384(trpS)
            HIN: HI0637(trpS)
            HPY: HP1253(trpS)
            BSU: trpS
            MGE: MG126(trpS)
            MPN: A65_orf346(trpS)
            SYN: slr1884(trpS)
            SCE: YDR268W(MSW1)
            HSA: WARS(IFP53)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.1.1.2
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.2
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