ENTRY       EC 6.1.1.15
NAME        Proline--tRNA ligase
            Prolyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Proline:tRNA(Pro) ligase (AMP-forming)
REACTION    ATP + L-Proline + tRNA(Pro) = AMP + Pyrophosphate +
            L-Prolyl-tRNA(Pro)
SUBSTRATE   ATP
            L-Proline
            tRNA(Pro)
PRODUCT     AMP
            Pyrophosphate
            L-Prolyl-tRNA(Pro)
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP01020  Protein biosynthesis (prokaryotes)
            PATH: MAP01030  Protein biosynthesis (eukaryotes)
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-G-
                         [HNTG]-[LIVMFYSTAGPC]
            PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
            PS: PS00762  Q-G-[DE]-x-[LIV]-[KR]-x(2)-K-x(2)-[KN]-[AS]-x(4)-[LIV]-
                         [DENK]-x(2)-V-x(2)-L-x(3)-K
GENES       MJA: MJ1238(proS)
            MTH: MTH611
            ECO: b0194(proS)
            HIN: HI0729(proS)
            HPY: HP0238(proS)
            BSU: proS
            MGE: MG283(proS)
            MPN: F11_orf483(proS)
            SYN: sll1425(proS)
            SCE: YER087W YHR020W
DBLINKS     University of Geneva ENZYME DATA BANK: 6.1.1.15
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.15
///