ENTRY       EC 4.6.1.5
NAME        Pentalenene synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     2-trans,6-trans-Farnesyldiphosphate pyrophosphate-lyase
            $ (cyclyzing, pentalenene-forming)
REACTION    2-trans,6-trans-Farnesyl diphosphate = Pentalenene + Pyrophosphate
SUBSTRATE   2-trans,6-trans-Farnesyl diphosphate
PRODUCT     Pentalenene
            Pyrophosphate
COMMENT     The initial step in the reaction is probably a cyclization of
            farnesyl diphosphate to form humulene. The enzyme is involved in
            the biosynthesis of pentalenolactone and related antibiotics.
DBLINKS     University of Geneva ENZYME DATA BANK: 4.6.1.5
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.5
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