ENTRY       EC 4.6.1.2
NAME        Guanylate cyclase
            Guanylyl cyclase
            Guanyl cyclase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     GTP pyrophosphate-lyase (cyclizing)
REACTION    GTP = 3',5'-Cyclic GMP + Pyrophosphate
SUBSTRATE   GTP
            ITP
            dGTP
PRODUCT     3',5'-Cyclic GMP
            Pyrophosphate
            3',5'-Cyclic IMP
            3',5'-Cyclic dGMP
COMMENT     Also acts on ITP and dGTP.
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 108960  Natriuretic peptide receptor A/guanylate cyclase A
            MIM: 108961  Natriuretic peptide receptor B/guanylate cyclase B
            MIM: 139396  Guanylate cyclase 1, soluble, alpha 3
            MIM: 139397  Guanylate cyclase 1, soluble, beta 3
            MIM: 300041  Guanylate cyclase 2F
            MIM: 600179  Guanylate cyclase 2D, membrane (retina-specific);
                         Leber congenital amaurosis, type I, 204000 (3)
            MIM: 601244  Guanylate cyclase 1, soluble, alpha 2
            MIM: 601330  Guanylate cyclase 2C (heat stable enterotoxin
                         receptor)
MOTIF       PS: PS00452  G-V-[LIVM]-x(0,1)-G-x(5)-[FY]-x-[LIVM]-[FYW]-[GS]-
                         [DNTHKW]-[DNT]-[IV]-[DNTA]-x(5)-[DE]
            PS: PS00458  G-P-x-C-x-Y-x-A-A-x-V-x-R-x(3)-H-W
            PS: PS50011  Protein kinase domain profile
DBLINKS     University of Geneva ENZYME DATA BANK: 4.6.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.2
///