ENTRY       EC 4.6.1.1
NAME        Adenylate cyclase
            Adenylylcyclase
            Adenyl cyclase
            3',5'-Cyclic AMP synthetase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     ATP pyrophosphate-lyase (cyclizing)
REACTION    ATP = 3',5'-Cyclic AMP + Pyrophosphate
SUBSTRATE   ATP
            dATP
PRODUCT     3',5'-Cyclic AMP
            3',5'-Cyclic dAMP
            Pyrophosphate
COFACTOR    Pyruvate
EFFECTOR    NAD+
COMMENT     Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate.
            Activated by NAD+ in the presence of EC 2.4.2.31.
            (EC 2.4.2.31 NAD(P)+-arginine ADP-ribosyltransferase)
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 103070  Adenylyl cyclase-8 (brain)
            MIM: 103071  Adenylyl cyclase-2, brain
            MIM: 103072  Adenylate cyclase-1 (brain)
            MIM: 600385  Adenylate cyclase 7
MOTIF       PS: PS00330  D-x-[LI]-x(4)-G-x-D-x-[LI]-x-G-G-x(3)-D
            PS: PS00452  G-V-[LIVM]-x(0,1)-G-x(5)-[FY]-x-[LIVM]-[FYW]-[GS]-
                         [DNTHKW]-[DNT]-[IV]-[DNTA]-x(5)-[DE]
            PS: PS01092  E-Y-F-G-A-S-L-W-x-L-Y-K
            PS: PS01093  Y-R-N-x-W-N-E-[LIVM]-R-T-L-H-F-x-G
GENES       ECO: b3806(cyaA)
            HIN: HI0604(cyaA)
            SYN: sll0646(cyaA) slr1991(cyaA)
            SCE: YJL005W(CYR1)
            HSA: ADCY1(Hs.139) ADCY2(HBAC2) ADCY3 ADCY4 ADCY5 ADCY6 ADCY7
                 ADCY8(ADCY3) ADCY9
STRUCTURES  PDB: 1AB8  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.6.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.1
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