ENTRY       EC 4.4.1.1
NAME        Cystathionine gamma-lyase
            Homoserine deaminase
            Homoserine dehydratase
            Cystine desulfhydrase
            Cysteine desulfhydrase
            gamma-Cystathionase
            Cystathionase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     Cystathione Lysteine-lyase (deaminating)
REACTION    L-Cystathionine + H2O = L-Cysteine + NH3 + 2-Oxobutanoate
SUBSTRATE   L-Cystathionine
            L-Homoserine
            L-Cystine
            L-Cysteine
            H2O
PRODUCT     L-Cysteine
            2-Oxobutanoate
            Thiocysteine
            Pyruvate
            H2S
            NH3
COFACTOR    Pyridoxal phosphate
EFFECTOR    Cysteine
COMMENT     A multifunctional pyridoxal-phosphate protein. Also catalyses
            elimination reactions of L-homoserine to form H2O, NH3, and
            2-oxobutanoate and of L-cystine, producing thiocysteine, pyruvate
            and NH3 and of L-cysteine producing pyruvate, NH3, and H2S.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00272  Cysteine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00868  [DQ]-[LIVM]-x(3)-[STAGC](2)-T-K-[FYW]-[LIVMF]-x-G-H-
                         [SGN]
GENES       SYN: cys3) slr0114(YAL012W
            SCE: YAL012W(CYS3)
            HSA: CTH(Hs.19904)
DBLINKS     University of Geneva ENZYME DATA BANK: 4.4.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.1
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