ENTRY       EC 4.2.99.8
NAME        Cysteine synthase
            O-Acetylserine (thiol)-lyase
            O-Acetylserine sulfhydrylase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O3-Acetyl-L-serine acetate-lyase (adding hydrogen sulfide)
REACTION    O3-Acetyl-L-serine + Hydrogen sulfide = L-Cysteine + Acetate
SUBSTRATE   O3-Acetyl-L-serine
            Hydrogen sulfide
            Alkyl thiol
            Cyanide
            Pyrazole
            Heterocyclic compound
PRODUCT     L-Cysteine
            Acetate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Some alkyl thiols, cyanide,
            pyrazole and some other heterocyclic compounds can act as
            acceptors. Not identical with EC 4.2.99.14-16.
PATHWAY     PATH: MAP00272  Cysteine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
MOTIF       PS: PS00868  [DQ]-[LIVM]-x(3)-[STAGC](2)-T-K-[FYW]-[LIVMF]-x-G-H-
                         [SGN]
            PS: PS00901  K-x-E-x(3)-[PA]-[STAGC]-x-S-[IV]-K-x-R-x-[STAG]-x(2)-M
GENES       ECO: b2414(cysK) b2420 b2421(cysM)
            HIN: HI1103(cysK)
            HPY: HP0107(cysK)
            BSU: cysK ytkP
            SYN: sll0712(cysM) slr1842(cysK)
            SCE: YGR012W
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.99.8
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.8
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