ENTRY       EC 4.2.99.10
NAME        O-Acetylhomoserine (thiol)-lyase
            Methionine synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O-Acetyl-L-homoserine acetate-lyase (adding methanethiol)
REACTION    O-Acetyl-L-homoserine + Methanethiol = L-Methionine + Acetate
SUBSTRATE   O-Acetyl-L-homoserine
            Methanethiol
            Thiol
            H2S
PRODUCT     L-Methionine
            Acetate
            L-Homocysteine
            Thioether
COMMENT     Also reacts with other thiols and H2S, producing homocysteine or
            thioethers. The name methionine synthase is more commonly applied
            to EC 2.1.1.13. An enzyme from baker's yeast also catalyses the
            reaction of EC 4.2.99.8, but more slowly.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00272  Cysteine metabolism
MOTIF       PS: PS00868  [DQ]-[LIVM]-x(3)-[STAGC](2)-T-K-[FYW]-[LIVMF]-x-G-H-
                         [SGN]
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.99.10
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.10
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