ENTRY       EC 4.2.1.33
NAME        3-Isopropylmalate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     3-Isopropylmalate hydro-lyase
REACTION    3-Isopropylmalate = 2-Isopropylmaleate + H2O
SUBSTRATE   2-Isopropylmalate
            2-Isopropylmaleate
            H2O
PRODUCT     2-Isopropylmaleate
            H2O
            3-Isopropylmalate
            3-Hydroxy-4-methyl-3-carboxypentanoate
COMMENT     The enzyme also hydrates the product to 3-hydroxy-4-methyl-
            3-carboxypentanoate thus bringing about an interconversion
            between the two isomers.
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
MOTIF       PS: PS00450  [LIVM]-x(4)-[LIVM]-[GST]-x-C-T-N-[GSTA]
GENES       MJA: MJ1271 MJ1277
            MTH: MTH1386 MTH1387 MTH1631 MTH829
            ECO: b0071(leuD) b0072(leuC)
            HIN: HI0988(leuC) HI0989(leuD)
            BSU: leuC leuD
            SYN: sll1444(leuD) sll1470(leuC)
            SCE: YGL009C(LEU1)
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.1.33
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.33
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