ENTRY       EC 4.2.1.3
NAME        Aconitate hydratase
            Aconitase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Citrate(isocitrate) hydro-lyase
REACTION    Citrate = Isocitrate
SUBSTRATE   Citrate
            cis-Aconitate
            H2O
            Isocitrate
PRODUCT     cis-Aconitate
            H2O
COFACTOR    Iron
            Sulfur
COMMENT     An iron-sulfur protein. cis-Aconitate is used to designate the
            isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. Also converts
            isocitrate into cis-aconitate.
            (Proc.Natl.Acad.Sci.USA (1991) 88, 10109-10113)
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
DISEASE     MIM: 100850  Aconitase, mitochondrial
MOTIF       PS: PS00450  [LIVM]-x(4)-[LIVM]-[GST]-x-C-T-N-[GSTA]
GENES       MJA: MJ0499
            ECO: b0118(acnB) b1276(acnA)
            BSU: citB
            SCE: YJL200C(J0327) YLR304C(ACO1)
            HSA: ACO1 ACO2(Hs.75900)
STRUCTURES  PDB: 7ACN  6ACN  1ACO  1AMJ  5ACN  1AMI  8ACN  1NIT  1NIS  1FGH  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.3
            SCOP (Structural Classificaion of Proteins): 4.2.1.3
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