ENTRY       EC 4.2.1.24
NAME        Porphobilinogen synthase
            Aminolevulinate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     5-Aminolevulinate hydro-lyase(adding 5-aminolevulinate and
            cyclizing)
REACTION    2 5-Aminolevulinate = Porphobilinogen + 2 H2O
SUBSTRATE   5-Aminolevulinate
PRODUCT     Porphobilinogen
            H2O
COFACTOR    Metal
COMMENT     The fungal enzyme is a metalloprotein.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DISEASE     MIM: 125270  Aminolevulinate, delta-, dehydratase; Porphyria, acute
                         hepatic (3); {Lead poisoning, susceptibility to} (3)
MOTIF       PS: PS00169  G-x-D-x-[LIVM](2)-[IV]-K-P-[GSA]-x(2)-Y
GENES       MJA: MJ0643(hemB)
            MTH: MTH744
            ECO: b0369(hemB)
            HPY: HP0163(hemB) HP1224(hemD)
            BSU: hemB
            SYN: sll1994(hemB)
            SCE: YGL040C(HEM2)
            HSA: ALAD
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.1.24
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.24
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