ENTRY       EC 4.2.1.20
NAME        Tryptophan synthase
            Tryptophan desmolase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Serine hydro-lyase (adding indoleglycerol-phosphate)
REACTION    L-Serine + 1-(Indol-3-yl)glycerol 3-phosphate =
            L-Tryptophan + Glyceraldehyde 3-phosphate
SUBSTRATE   L-Serine
            1-(Indol-3-yl)glycerol 3-phosphate
            Indole
            Indoleglycerol phosphate
PRODUCT     L-Tryptophan
            Glyceraldehyde 3-phosphate
            H2O
            Indole
INHIBITOR   1-(Indol-3-yl)propanol 3-phosphate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also catalyses the conversion of
            serine and indole into tryptophan and water and of indoleglycerol
            phosphate into indole and glyceraldehyde phosphate (the latter
            reaction formerly listed as EC 4.1.2.8). In some organisms, this
            enzyme is part of a multifunctional protein together with one or
            more other components of the system for biosynthesis of tryptophan
            (EC 2.4.2.18, 4.1.1.48, 4.1.3.27, 5.3.1.24).
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
MOTIF       PS: PS00167  [LIVM]-E-[LIVM]-G-x(2)-[FYC]-[ST]-[DE]-[PA]-[LIVMY]-
                         [AGLI]-[DE]-G
            PS: PS00168  [LIVM]-x-H-x-G-[STA]-H-K-x-N
GENES       MJA: MJ1037(trpB) MJ1038(trpA)
            MTH: MTH1476 MTH1659(trpB) MTH1660(trpA)
            ECO: b1260(trpA) b1261(trpB)
            HIN: HI1431(trpB) HI1432(trpA)
            HPY: HP1277(trpA) HP1278(trpB)
            BSU: trpA trpB
            SYN: slr0543(trpB) slr0966(trpA)
            SCE: YGL026C(TRP5)
STRUCTURES  PDB: 2TYS  2TSY  2TRS  1WSY  1TTQ  1UBS  1TTP  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.1.20
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.20
            SCOP (Structural Classificaion of Proteins): 4.2.1.20
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