ENTRY       EC 4.2.1.2
NAME        Fumarate hydratase
            Fumarase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (S)-Malate hydro-lyase
REACTION    (S)-Malate = Fumarate + H2O
SUBSTRATE   (S)-Malate
PRODUCT     Fumarate
            H2O
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
DISEASE     MIM: 136850  Fumarate hydratase; Fumarase deficiency (3)
MOTIF       PS: PS00163  G-S-x(2)-M-x(2)-K-x-N
GENES       MJA: MJ0617 MJ1294
            MTH: MTH1115 MTH1735 MTH1910 MTH963
            ECO: b1611(fumC) b1612(fumA) b4122(fumB)
            HPY: HP1325(fumC)
            BSU: citG
            SYN: slr0018(fumC)
            SCE: YPL262W(FUM1)
            HSA: FH(Hs.75653)
STRUCTURES  PDB: 1FUQ  1FUP  1FUO  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.2
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