ENTRY       EC 4.2.1.17
NAME        Enoyl-CoA hydratase
            Enoyl hydrase
            Unsaturated acyl-CoA hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (3S)-3-Hydroxyacyl-CoA hydro-lyase
REACTION    (3S)-3-Hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O;
            (3R)-3-Hydroxyacyl-CoA = cis-2,3-Dehydroacyl-CoA + H2O;
SUBSTRATE   (3S)-3-Hydroxyacyl-CoA
            (3R)-3-Hydroxyacyl-CoA
            2-Methylprop-2-enoyl-CoA
            2-Methylbut-2-enoyl-CoA
            3-Methylbut-2-enoyl-CoA
PRODUCT     trans-2,3-Dehydroacyl-CoA
            cis-2,3-Dehydroacyl-CoA
            H2O
            3-Hydroxy-2-methylpropanoyl-CoA
            (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
            trans-3-Methylglutaconyl-CoA
COMMENT     Acts in the reverse direction. With cis-compounds, yields
            (3R)-3-hydroxyacyl-CoA. (cf. EC 4.2.1.74 Long-chain-enoyl-CoA
            hydratase)
PATHWAY     PATH: MAP00062  Fatty acid biosynthesis (path 2)
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00310  Lysine degradation
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
DISEASE     MIM: 143450  Hydroxyacyl-Coenzyme A
                         dehydrogenase/3-ketoacyl-Coenzyme A thiolase;
                         Trifunctional protein deficiency, type II (3)
            MIM: 600696  Enoyl Coenzyme A hydratase 1, peroxisomal
            MIM: 600890  Hydroxyacyl-Coenzyme A
                         dehydrogenase/3-ketoacyl-Coenzyme A thiolase/; LCHAD
                         deficiency (3); Mitochondrial trifunctional protein
                         deficiency (1)
MOTIF       PS: PS00067  [DNE]-x(2)-G-F-[LIVMFY]-x-[NT]-R-x(3)-[PA]-[LIVMFY](2)-
                         x(5)-[LIVMFYC]-[LIVMFY]-x(2)-G
            PS: PS00166  [LIVM]-[STA]-x-[LIVM]-[DNQRSTA]-G-x(3)-[AG](3)-x(4)-
                         [LIVMS]-x-[CSTA]-[DQHP]-[LIVMFY]
            PS: PS00342  [SAGCN]-[RKH]-[LIVMAF]>
GENES       ECO: b1393(ydbS) b3846(fadB)
STRUCTURES  PDB: 1DUB  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.1.17
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.17
///