ENTRY       EC 4.2.1.11
NAME        Phosphopyruvate hydratase
            Enolase
            2-Phosphoglycerate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2-Phospho-D-glucerate hydro-lyase
REACTION    2-Phospho-D-glycerate = Phosphoenolpyruvate + H2O;
            3-Phospho-D-erythronate =
            Phosphoenol-4-deoxy-3-tetrulosonate + H2O
SUBSTRATE   2-Phospho-D-glycerate
            3-Phospho-D-erythronate
PRODUCT     Phosphoenolpyruvate
            H2O
            Phosphoenol-4-deoxy-3-tetrulosonate
INHIBITOR   Phosphonoacetohydroxamate
COMMENT     Also acts on 3-phospho-D-erythronate.
            Ki of phosphonoacetohydroxamate is 15 picoM as the trianion with
            saturation Mg++ ion (Biochemistry, 1984, 23, 2779).  Crystal
            structure of the inhibitor complex (Biochemistry, 1994, 33,
            6295-6300).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
DISEASE     MIM: 131360  Enolase-2, gamma, neuronal
            MIM: 131370  Enolase-3, beta, muscle
            MIM: 172430  Enolase-1, alpha; Enolase deficiency (1)
MOTIF       PS: PS00164  D-D-L-x-V-[STA]-[NK]-[PTV]
GENES       MJA: MJ0232(eno)
            MTH: MTH43
            ECO: b2779(eno)
            HIN: HI0932(eno)
            HPY: HP0154(eno)
            BSU: eno
            MGE: MG407(eno)
            MPN: C12_orf456(eno)
            SYN: slr0752(eno)
            SCE: YGR254W(ENO1) YHR174W(ENO2) YMR323W(ERR1) YOR393W(ERR1)
            HSA: ENO1(Hs.675) ENO2(Hs.75675) ENO3(Hs.99986)
STRUCTURES  PDB: 3ENL  4ENL  1NEL  6ENL  7ENL  1PDZ  1EBG  1PDY  1EBH  1ELS  
                 1ONE  5ENL  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.1.11
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.11
            SCOP (Structural Classificaion of Proteins): 4.2.1.11
///