ENTRY       EC 4.2.1.1
NAME        Carbonate dehydratase
            Carbonic anhydrase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Carbonate hydro-lyase
REACTION    H2CO3 = CO2 + H2O
SUBSTRATE   H2CO3
PRODUCT     CO2
            H2O
COFACTOR    Zinc
COMMENT     A zinc protein.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
DISEASE     MIM: 114750  Carbonic anhydrase III
            MIM: 114760  Carbonic anhydrase IV
            MIM: 114761  Carbonic anhydrase V (mitochondrial)
            MIM: 114770  Carbonic anhydrase VII
            MIM: 114780  Carbonic anhydrase VI
            MIM: 114800  Carbonic anhydrase I
            MIM: 114815  Carbonic anhydrase VIII
            MIM: 259730  Carbonic anhydrase II; Renal tubular
                         acidosis-osteopetrosis syndrome (3)
MOTIF       PS: PS00162  S-E-H-x-[LIVM]-x(4)-[FYH]-x(2)-E-[LIVM]-H-[LIVMFA](2)
            PS: PS00704  C-[SA]-D-S-R-[LIVM]-x-[AP]
            PS: PS00705  [EQ]-Y-A-[LIVM]-x(2)-[LIVM]-x(4)-[LIVMF](3)-x-G-H-x(2)-
                         C-G
GENES       MTH: MTH1582
            ECO: b0339(cynT)
            HPY: HP0004(icfA)
            SYN: slr0051(icfA) slr1347(icfA)
            HSA: CA1(Hs.23118) CA2(Hs.89748) CA3 CA4(CAIV) CA5(Hs.137)
                 CA6(Hs.73855) CA7
STRUCTURES  PDB: 12CA  1AZM  1BCD  1BIC  1BZM  1CA2  1CA3  1CAH  1CAI  1CAJ  
                 1CAK  1CAL  1CAM  1CAN  1CAO  1CAY  1CAZ  1CCS  1CCT  1CCU  
                 1CIL  1CIM  1CIN  1CNB  1CNC  1CNG  1CNH  1CNI  1CNJ  1CNK  
                 1CNW  1CNX  1CNY  1CRA  1CRM  1CVA  1CVB  1CVC  1CVD  1CVE  
                 1CVF  1CVH  1CZM  1DCA  1DCB  1DMX  1DMY  1HCA  1HCB  1HEA  
                 1HEB  1HEC  1HED  1HUG  1HUH  1HVA  1MUA  1OKL  1OKM  1OKN  
                 1RAY  1RAZ  1RZA  1RZB  1RZC  1RZD  1RZE  1THJ  1UGA  1UGB  
                 1UGC  1UGD  1UGE  1UGF  1UGG  1URT  1YDA  1YDB  1YDC  1YDD  
                 1ZSA  1ZSB  1ZSC  2CA2  2CAB  2CBA  2CBB  2CBC  2CBD  2CBE  
                 3CA2  4CA2  4CAC  5CA2  5CAC  6CA2  7CA2  8CA2  9CA2  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.1
            SCOP (Structural Classificaion of Proteins): 4.2.1.1
///