ENTRY       EC 4.1.99.1
NAME        Tryptophanase
CLASS       Lyases
            Carbon-carbon lyases
            Other carbon-carbon lyases
SYSNAME     L-Tryotophan indole-lyase (deaminating)
REACTION    L-Tryptophan + H2O = Indole + Pyruvate + NH3
SUBSTRATE   L-Tryptophan
            H2O
PRODUCT     Indole
            Pyruvate
            NH3
COFACTOR    Pyridoxal phosphate
            K+
COMMENT     A pyridoxal-phosphate protein, requiring K+. Also catalyses
            2,3-elimination and beta-replacement reactions of some indole-
            substituted tryptophan analogs of L-cysteine, L-serine and other
            3-substituted amino acids.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00853  Y-x-D-x(3)-M-S-[GA]-K-K-D-x-[LIVM](2)-x-[LIVM]-G-G
GENES       ECO: b3708(tnaA)
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.99.1
            WIT (What Is There) Metabolic Reconstruction: 4.1.99.1
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