ENTRY       EC 4.1.3.8
NAME        ATP citrate (pro-S)-lyase
            Citrate cleavage enzyme
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     ATP:citrate oxaloacetate-lyase ((pro-3S)-CH2COO- ->acetyl-CoA)
            (ATP-dephosphorylating)
REACTION    ATP + Citrate + CoA = ADP + Orthophosphate + Acetyl-CoA +
            Oxaloacetate
SUBSTRATE   ATP
            Citrate
            CoA
PRODUCT     ADP
            Orthophosphate
            Acetyl-CoA
            Oxaloacetate
COMMENT     The enzyme can be dissociated into components, two of which are
            identical with EC 4.1.3.34 and 6.2.1.18.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
DISEASE     MIM: 108728  ATP citrate lyase
MOTIF       PS: PS00399  [LIVMF]-G-H-A-G-A
GENES       HSA: ACLY
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.3.8
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.8
///