ENTRY       EC 4.1.3.5
NAME        Hydroxymethylglutaryl-CoA synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase
            (CoA-acetylating)
REACTION    (S)-3-Hydroxy-3-methylglutaryl-CoA + CoA = Acetyl-CoA +
            H2O + Acetoacetyl-CoA
SUBSTRATE   (S)-3-Hydroxy-3-methylglutaryl-CoA
            CoA
PRODUCT     Acetyl-CoA
            H2O
            Acetoacetyl-CoA
PATHWAY     PATH: MAP00072  Synthesis and degradation of ketone bodies
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00650  Butanoate metabolism
DISEASE     MIM: 142940  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
            MIM: 600234  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
GENES       SCE: YML126C(HMGC)
            HSA: HMGCS1(HMGCS)
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.3.5
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.5
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