ENTRY EC 4.1.3.27
NAME Anthranilate synthase
CLASS Lyases
Carbon-carbon lyases
Oxo-acid-lyases
SYSNAME Chorismate pyruvate-lyase (amino-accepting)
REACTION Chorismate + L-Glutamine = Anthranilate + Pyruvate + L-Glutamate
SUBSTRATE Chorismate
L-Glutamine
NH3
PRODUCT Anthranilate
Pyruvate
L-Glutamate
COMMENT In some organisms, this enzyme is part of a multifunctional
protein together with one or more other components of the system
for biosymthesis of tryptophan (EC 2.4.2.18, 4.1.1.48, 4.2.1.20,
5.3.1.24). The native enzyme in the complex uses either glutamine
or, less efficiently, NH3. The enzyme separated from the complex
uses NH3 only.
Glutamine amidotransferase domian (type G) has SH protease-
like catalytic residues.
PATHWAY PATH: MAP00130 Ubiquinone biosynthesis
PATH: MAP00400 Phenylalanine, tyrosine and tryptophan biosynthesis
MOTIF PS: PS00442 [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
[QE]-x-[LIVMFA]
PS: PS00614 [LIVMFY]-[LIVMC]-x-E-[LIVMFYC]-K-[KRSP]-[ATK]-S-P-[ST]-
x(3)-[LIVMFYST]
GENES MJA: MJ0234(trpD) MJ0238(trpG) MJ1075(trpE)
MTH: MTH1655(trpE) MTH1656(trpG)
ECO: b1263(trpD) b1264(trpE)
HIN: HI1171(trpG) HI1387(trpE)
HPY: HP1282(trpE)
BSU: trpE
SYN: slr0055(trpG) slr0738(trpE) slr1979(trpE)
SCE: YER090W(TRP2) YKL211C(TRP3)
STRUCTURES PDB: 1CSM
DBLINKS University of Geneva ENZYME DATA BANK: 4.1.3.27
WIT (What Is There) Metabolic Reconstruction: 4.1.3.27
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