ENTRY       EC 4.1.3.21
NAME        Homocitrate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     2-Hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase
            (CoA-acetylating)
REACTION    2-Hydroxybutane-1,2,4-tricarboxylate + CoA =
            Acetyl-CoA + H2O + 2-Oxoglutarate
SUBSTRATE   2-Hydroxybutane-1,2,4-tricarboxylate
            CoA
PRODUCT     Acetyl-CoA
            H2O
            2-Oxoglutarate
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00620  Pyruvate metabolism
MOTIF       PS: PS00815  L-R-D-G-x-Q-x(10)-K
            PS: PS00816  [LIVMF]-x(2)-H-x-H-[DN]-D-x-G-x-[GAS]-x-[GAS]
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.3.21
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.21
///