ENTRY       EC 4.1.3.12
NAME        2-Isopropylmalate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-
            lyase (CoA-acetylating)
REACTION    3-Carboxy-3-hydroxy-4-methylpentanoate + CoA = Acetyl-CoA +
            3-Methyl-2-oxobutanoate + H2O
SUBSTRATE   3-Carboxy-3-hydroxy-4-methylpentanoate
            CoA
PRODUCT     Acetyl-CoA
            3-Methyl-2-oxobutanoate
            H2O
COFACTOR    K+
COMMENT     Requires K+.
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00620  Pyruvate metabolism
MOTIF       PS: PS00815  L-R-D-G-x-Q-x(10)-K
            PS: PS00816  [LIVMF]-x(2)-H-x-H-[DN]-D-x-G-x-[GAS]-x-[GAS]
GENES       MTH: MTH1481 MTH1630 MTH723
            ECO: b0074(leuA)
            HIN: HI0986(leuA)
            BSU: leuA
            SYN: sll1564(leuA) slr0186(leuA)
            SCE: YNL104C(LEU4)
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.3.12
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.12
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