ENTRY       EC 4.1.1.64
NAME        2,2-Dialkylglycine decarboxylase (pyruvate)
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     2,2-Dialkylglycine carboxylyase(amino-transferring)
REACTION    2,2-Dialkylglycine + Pyruvate = Dialkyl ketone + CO2 + L-Alanine
SUBSTRATE   2,2-Dialkylglycine
            Pyruvate
            2-Amino-2-methylpropanoate
            2-Amino-2-methylbutanoate
            1-Aminocyclopentanecarboxylate
PRODUCT     Dialkyl ketone
            CO2
            L-Alanine
            Acetone
            Methyl ethyl ketone
            Cyclopentanone
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Acts on 2-amino-2-methylpropanoate
            (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and
            1-aminocyclopentanecarboxylate.
MOTIF       PS: PS00600  [LIVMFYW](2)-x-D-E-[LIVMA]-x(2)-[GP]-[LIVMFYWAG]-
                         x(0,1)-[SACR]-x-[GSAD]-x(12,16)-D-[LIVMFYW]-x(2,3)-
                         [GSA]-K-x(3)-[GSTADN]-[GSA]
STRUCTURES  PDB: 1DGD  1DGE  1DKA  2DKB  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.1.64
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.64
            SCOP (Structural Classificaion of Proteins): 4.1.1.64
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