ENTRY       EC 4.1.1.48
NAME        Indole-3-glycerol-phosphate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
            carboxy-lyase(cyclizing)
REACTION    1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate =
            1-(Indol-3-yl)glycerol 3-phosphate + CO2 + H2O
SUBSTRATE   1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
PRODUCT     1-(Indol-3-yl)glycerol 3-phosphate
            CO2
            H2O
COFACTOR    Pyruvate
COMMENT     In some organisms, this enzyme is part of a multifunctional
            protein together with one or more other components of the system
            for the biosynthesis of tryptophan (EC 2.4.2.18, 4.1.3.27,
            4.2.1.20, 5.3.1.24).
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QE]-x-[LIVMFA]
            PS: PS00614  [LIVMFY]-[LIVMC]-x-E-[LIVMFYC]-K-[KRSP]-[ATK]-S-P-[ST]-
                         x(3)-[LIVMFYST]
GENES       MJA: MJ0918(trpC)
            MTH: MTH1657(trpC)
            ECO: b1262(trpC)
            HIN: HI1389B(trpC)
            BSU: trpC
            SYN: slr0546(trpC)
            SCE: YKL211C(TRP3)
STRUCTURES  PDB: 1JUK  1JUL  1PII  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.1.48
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.48
            SCOP (Structural Classificaion of Proteins): 4.1.1.48
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