ENTRY       EC 4.1.1.28
NAME        Aromatic-L-amino-acid decarboxylase
            Dopa decarboxylase
            Tryptophan decarboxylase
            Hydroxytryptophan decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Aromatic-L-amino-acid decarboxy-lyase
REACTION    L-Tryptophan = Tryptamine + CO2
SUBSTRATE   L-Tryptophan
            5-Hydroxy-L-tryptophan
            Dihydroxy-L-phenylalanine
PRODUCT     Tryptamine
            CO2
COFACTOR    Pyridoxal phosphate
            Pyrroloquinoline quinone
COMMENT     A pyridoxal-phosphate protein. The enzyme acts on L-tryptophan,
            5-hydroxy-L-tryptophan and dihydroxy-L-phenylalanine.
            PQQ: Groen,B.W., van der Meer,R.A., Duine,J.A. FEBS Lett. 1988.
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
DISEASE     MIM: 107930  DOPA decarboxylase (aromatic L-amino acid
                         decarboxylase)
MOTIF       PS: PS00392  S-[LIVMFYW]-x(5)-K-[LIVMFYWG](2)-x(3)-[LIVMFYW]-x-[CA]-
                         x(2)-[LIVMFYW]-x(2)-[RK]
GENES       HSA: DDC(Hs.475)
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.1.28
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.28
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